The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
Identifieur interne : 001575 ( Main/Exploration ); précédent : 001574; suivant : 001576The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
Auteurs : Janelle Drouin-Ouellet [Canada] ; Claire Gibrat [Canada] ; Mélanie Bousquet [Canada] ; Frédéric Calon [Canada] ; Jasna Kriz [Canada] ; Francesca Cicchetti [Canada]Source :
- Journal of Neuroinflammation [ 1742-2094 ] ; 2011.
Abstract
Mounting evidence supports a significant role of inflammation in Parkinson's disease (PD) pathophysiology, with several inflammatory pathways being suggested as playing a role in the dopaminergic degeneration seen in humans and animal models of the disease. These include tumor necrosis factor, prostaglandins and oxidative-related stress components. However, the role of innate immunity has not been established in PD.
Based on the fact that the myeloid differentiation primary response gene (88) (MyD88) is the most common adaptor protein implicated in toll-like receptor (TLR) signaling, critical in the innate immune response, we undertook a study to investigate the potential contribution of this specific pathway to MPTP-induced brain dopaminergic degeneration using MyD88 knock out mice (MyD88-/-), following our observations that the MyD88-dependent pathway was critical for MPTP dopaminergic toxicity in the enteric nervous system. Post-mortem analyses assessing nigrostriatal dopaminergic degeneration and inflammation were performed using HPLC, western blots, autoradiography and immunofluorescence.
Our results demonstrate that MyD88-/- mice are as vulnerable to MPTP-induced dopamine and DOPAC striatal depletion as wild type mice. Furthermore, MyD88-/- mice show similar striatal dopamine transporter and tyrosine hydroxylase loss, as well as dopaminergic cell loss in the substantia nigra pars compacta in response to MPTP. To evaluate the extent of the inflammatory response created by the MPTP regimen utilized, we further performed bioluminescence imaging using TLR2-luc/gfp transgenic mice and microglial density analysis, which revealed a modest brain microglial response following MPTP. This was accompanied by a significant astrocytic reaction in the striatum, which was of similar magnitude both in wild type and MyD88-/- mice.
Our results suggest that subacute MPTP-induced dopaminergic degeneration observed in the central nervous system is MyD88-independent, in contrast to our recent observations that this pathway, in the same cohort of animals, is critical in the loss of dopaminergic neurons in the enteric nervous system.
Url:
DOI: 10.1186/1742-2094-8-137
PubMed: 21989292
PubMed Central: 3203853
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A22
- to stream Pmc, to step Curation: 000A22
- to stream Pmc, to step Checkpoint: 000889
- to stream Ncbi, to step Merge: 000F76
- to stream Ncbi, to step Curation: 000F76
- to stream Ncbi, to step Checkpoint: 000F76
- to stream Main, to step Merge: 001639
- to stream Main, to step Curation: 001575
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration</title><author><name sortKey="Drouin Ouellet, Janelle" sort="Drouin Ouellet, Janelle" uniqKey="Drouin Ouellet J" first="Janelle" last="Drouin-Ouellet">Janelle Drouin-Ouellet</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation></author><author><name sortKey="Gibrat, Claire" sort="Gibrat, Claire" uniqKey="Gibrat C" first="Claire" last="Gibrat">Claire Gibrat</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation></author><author><name sortKey="Bousquet, Melanie" sort="Bousquet, Melanie" uniqKey="Bousquet M" first="Mélanie" last="Bousquet">Mélanie Bousquet</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation></author><author><name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frédéric" last="Calon">Frédéric Calon</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation><affiliation><nlm:aff id="I2">Faculté de Pharmacie, Université Laval, 1050, avenue de la Médecine, Québec, G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">G1V 0A6 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Kriz, Jasna" sort="Kriz, Jasna" uniqKey="Kriz J" first="Jasna" last="Kriz">Jasna Kriz</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation><affiliation><nlm:aff id="I3">Département de Psychiatrie & Neurosciences, Université Laval, 1050, avenue de la Médecine, Québec, G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">G1V 0A6 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Cicchetti, Francesca" sort="Cicchetti, Francesca" uniqKey="Cicchetti F" first="Francesca" last="Cicchetti">Francesca Cicchetti</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation><affiliation><nlm:aff id="I3">Département de Psychiatrie & Neurosciences, Université Laval, 1050, avenue de la Médecine, Québec, G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">G1V 0A6 Canada</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21989292</idno><idno type="pmc">3203853</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203853</idno><idno type="RBID">PMC:3203853</idno><idno type="doi">10.1186/1742-2094-8-137</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000A22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A22</idno><idno type="wicri:Area/Pmc/Curation">000A22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A22</idno><idno type="wicri:Area/Pmc/Checkpoint">000889</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000889</idno><idno type="wicri:Area/Ncbi/Merge">000F76</idno><idno type="wicri:Area/Ncbi/Curation">000F76</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F76</idno><idno type="wicri:Area/Main/Merge">001639</idno><idno type="wicri:Area/Main/Curation">001575</idno><idno type="wicri:Area/Main/Exploration">001575</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration</title><author><name sortKey="Drouin Ouellet, Janelle" sort="Drouin Ouellet, Janelle" uniqKey="Drouin Ouellet J" first="Janelle" last="Drouin-Ouellet">Janelle Drouin-Ouellet</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation></author><author><name sortKey="Gibrat, Claire" sort="Gibrat, Claire" uniqKey="Gibrat C" first="Claire" last="Gibrat">Claire Gibrat</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation></author><author><name sortKey="Bousquet, Melanie" sort="Bousquet, Melanie" uniqKey="Bousquet M" first="Mélanie" last="Bousquet">Mélanie Bousquet</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation></author><author><name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frédéric" last="Calon">Frédéric Calon</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation><affiliation><nlm:aff id="I2">Faculté de Pharmacie, Université Laval, 1050, avenue de la Médecine, Québec, G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">G1V 0A6 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Kriz, Jasna" sort="Kriz, Jasna" uniqKey="Kriz J" first="Jasna" last="Kriz">Jasna Kriz</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation><affiliation><nlm:aff id="I3">Département de Psychiatrie & Neurosciences, Université Laval, 1050, avenue de la Médecine, Québec, G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">G1V 0A6 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Cicchetti, Francesca" sort="Cicchetti, Francesca" uniqKey="Cicchetti F" first="Francesca" last="Cicchetti">Francesca Cicchetti</name><affiliation wicri:level="1"><nlm:aff id="I1">Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Axe Neurosciences, Centre de Recherche du CHUL (CHUQ), T2-50, 2705 Boulevard Laurier, Québec, G1V 4G2</wicri:regionArea><wicri:noRegion>G1V 4G2</wicri:noRegion></affiliation><affiliation><nlm:aff id="I3">Département de Psychiatrie & Neurosciences, Université Laval, 1050, avenue de la Médecine, Québec, G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">G1V 0A6 Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Neuroinflammation</title><idno type="eISSN">1742-2094</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Mounting evidence supports a significant role of inflammation in Parkinson's disease (PD) pathophysiology, with several inflammatory pathways being suggested as playing a role in the dopaminergic degeneration seen in humans and animal models of the disease. These include tumor necrosis factor, prostaglandins and oxidative-related stress components. However, the role of innate immunity has not been established in PD.</p></sec><sec><title>Methods</title><p>Based on the fact that the myeloid differentiation primary response gene (88) (MyD88) is the most common adaptor protein implicated in toll-like receptor (TLR) signaling, critical in the innate immune response, we undertook a study to investigate the potential contribution of this specific pathway to MPTP-induced brain dopaminergic degeneration using MyD88 knock out mice (MyD88-/-), following our observations that the MyD88-dependent pathway was critical for MPTP dopaminergic toxicity in the enteric nervous system. Post-mortem analyses assessing nigrostriatal dopaminergic degeneration and inflammation were performed using HPLC, western blots, autoradiography and immunofluorescence.</p></sec><sec><title>Results</title><p>Our results demonstrate that MyD88-/- mice are as vulnerable to MPTP-induced dopamine and DOPAC striatal depletion as wild type mice. Furthermore, MyD88-/- mice show similar striatal dopamine transporter and tyrosine hydroxylase loss, as well as dopaminergic cell loss in the substantia nigra pars compacta in response to MPTP. To evaluate the extent of the inflammatory response created by the MPTP regimen utilized, we further performed bioluminescence imaging using TLR2-luc/gfp transgenic mice and microglial density analysis, which revealed a modest brain microglial response following MPTP. This was accompanied by a significant astrocytic reaction in the striatum, which was of similar magnitude both in wild type and MyD88-/- mice.</p></sec><sec><title>Conclusions</title><p>Our results suggest that subacute MPTP-induced dopaminergic degeneration observed in the central nervous system is MyD88-independent, in contrast to our recent observations that this pathway, in the same cohort of animals, is critical in the loss of dopaminergic neurons in the enteric nervous system.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author><author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgeer, Pl" uniqKey="Mcgeer P">PL McGeer</name></author><author><name sortKey="Mcgeer, Eg" uniqKey="Mcgeer E">EG McGeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banati, Rb" uniqKey="Banati R">RB Banati</name></author><author><name sortKey="Daniel, Se" uniqKey="Daniel S">SE Daniel</name></author><author><name sortKey="Blunt, Sb" uniqKey="Blunt S">SB Blunt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boka, G" uniqKey="Boka G">G Boka</name></author><author><name sortKey="Anglade, P" uniqKey="Anglade P">P Anglade</name></author><author><name sortKey="Wallach, D" uniqKey="Wallach D">D Wallach</name></author><author><name sortKey="Javoy Agid, F" uniqKey="Javoy Agid F">F Javoy-Agid</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Damier, P" uniqKey="Damier P">P Damier</name></author><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author><author><name sortKey="Zhang, P" uniqKey="Zhang P">P Zhang</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Javoy Agid, F" uniqKey="Javoy Agid F">F Javoy-Agid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name></author><author><name sortKey="Boissiere, F" uniqKey="Boissiere F">F Boissiere</name></author><author><name sortKey="Faucheux, B" uniqKey="Faucheux B">B Faucheux</name></author><author><name sortKey="Brugg, B" uniqKey="Brugg B">B Brugg</name></author><author><name sortKey="Mouatt Prigent, A" uniqKey="Mouatt Prigent A">A Mouatt-Prigent</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name></author><author><name sortKey="Dugas, N" uniqKey="Dugas N">N Dugas</name></author><author><name sortKey="Faucheux, B" uniqKey="Faucheux B">B Faucheux</name></author><author><name sortKey="Hartmann, A" uniqKey="Hartmann A">A Hartmann</name></author><author><name sortKey="Tardieu, M" uniqKey="Tardieu M">M Tardieu</name></author><author><name sortKey="Debre, P" uniqKey="Debre P">P Debre</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Dugas, B" uniqKey="Dugas B">B Dugas</name></author><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imamura, K" uniqKey="Imamura K">K Imamura</name></author><author><name sortKey="Hishikawa, N" uniqKey="Hishikawa N">N Hishikawa</name></author><author><name sortKey="Sawada, M" uniqKey="Sawada M">M Sawada</name></author><author><name sortKey="Nagatsu, T" uniqKey="Nagatsu T">T Nagatsu</name></author><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name></author><author><name sortKey="Hashizume, Y" uniqKey="Hashizume Y">Y Hashizume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knott, C" uniqKey="Knott C">C Knott</name></author><author><name sortKey="Stern, G" uniqKey="Stern G">G Stern</name></author><author><name sortKey="Wilkin, Gp" uniqKey="Wilkin G">GP Wilkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgeer, Pl" uniqKey="Mcgeer P">PL McGeer</name></author><author><name sortKey="Itagaki, S" uniqKey="Itagaki S">S Itagaki</name></author><author><name sortKey="Boyes, Be" uniqKey="Boyes B">BE Boyes</name></author><author><name sortKey="Mcgeer, Eg" uniqKey="Mcgeer E">EG McGeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogi, M" uniqKey="Mogi M">M Mogi</name></author><author><name sortKey="Harada, M" uniqKey="Harada M">M Harada</name></author><author><name sortKey="Kondo, T" uniqKey="Kondo T">T Kondo</name></author><author><name sortKey="Narabayashi, H" uniqKey="Narabayashi H">H Narabayashi</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Nagatsu, T" uniqKey="Nagatsu T">T Nagatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogi, M" uniqKey="Mogi M">M Mogi</name></author><author><name sortKey="Harada, M" uniqKey="Harada M">M Harada</name></author><author><name sortKey="Kondo, T" uniqKey="Kondo T">T Kondo</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Inagaki, H" uniqKey="Inagaki H">H Inagaki</name></author><author><name sortKey="Minami, M" uniqKey="Minami M">M Minami</name></author><author><name sortKey="Nagatsu, T" uniqKey="Nagatsu T">T Nagatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogi, M" uniqKey="Mogi M">M Mogi</name></author><author><name sortKey="Harada, M" uniqKey="Harada M">M Harada</name></author><author><name sortKey="Kondo, T" uniqKey="Kondo T">T Kondo</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Nagatsu, T" uniqKey="Nagatsu T">T Nagatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogi, M" uniqKey="Mogi M">M Mogi</name></author><author><name sortKey="Harada, M" uniqKey="Harada M">M Harada</name></author><author><name sortKey="Kondo, T" uniqKey="Kondo T">T Kondo</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Nagatsu, T" uniqKey="Nagatsu T">T Nagatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogi, M" uniqKey="Mogi M">M Mogi</name></author><author><name sortKey="Harada, M" uniqKey="Harada M">M Harada</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Narabayashi, H" uniqKey="Narabayashi H">H Narabayashi</name></author><author><name sortKey="Fujita, K" uniqKey="Fujita K">K Fujita</name></author><author><name sortKey="Nagatsu, T" uniqKey="Nagatsu T">T Nagatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Zhang, Sm" uniqKey="Zhang S">SM Zhang</name></author><author><name sortKey="Hernan, Ma" uniqKey="Hernan M">MA Hernan</name></author><author><name sortKey="Schwarzschild, Ma" uniqKey="Schwarzschild M">MA Schwarzschild</name></author><author><name sortKey="Willett, Wc" uniqKey="Willett W">WC Willett</name></author><author><name sortKey="Colditz, Ga" uniqKey="Colditz G">GA Colditz</name></author><author><name sortKey="Speizer, Fe" uniqKey="Speizer F">FE Speizer</name></author><author><name sortKey="Ascherio, A" uniqKey="Ascherio A">A Ascherio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernan, Ma" uniqKey="Hernan M">MA Hernan</name></author><author><name sortKey="Logroscino, G" uniqKey="Logroscino G">G Logroscino</name></author><author><name sortKey="Garcia Rodriguez, La" uniqKey="Garcia Rodriguez L">LA Garcia Rodriguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ton, Tg" uniqKey="Ton T">TG Ton</name></author><author><name sortKey="Heckbert, Sr" uniqKey="Heckbert S">SR Heckbert</name></author><author><name sortKey="Longstreth, Wt" uniqKey="Longstreth W">WT Longstreth</name></author><author><name sortKey="Rossing, Ma" uniqKey="Rossing M">MA Rossing</name></author><author><name sortKey="Kukull, Wa" uniqKey="Kukull W">WA Kukull</name></author><author><name sortKey="Franklin, Gm" uniqKey="Franklin G">GM Franklin</name></author><author><name sortKey="Swanson, Pd" uniqKey="Swanson P">PD Swanson</name></author><author><name sortKey="Smith Weller, T" uniqKey="Smith Weller T">T Smith-Weller</name></author><author><name sortKey="Checkoway, H" uniqKey="Checkoway H">H Checkoway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akiyama, H" uniqKey="Akiyama H">H Akiyama</name></author><author><name sortKey="Mcgeer, Pl" uniqKey="Mcgeer P">PL McGeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cicchetti, F" uniqKey="Cicchetti F">F Cicchetti</name></author><author><name sortKey="Brownell, Al" uniqKey="Brownell A">AL Brownell</name></author><author><name sortKey="Williams, K" uniqKey="Williams K">K Williams</name></author><author><name sortKey="Chen, Yi" uniqKey="Chen Y">YI Chen</name></author><author><name sortKey="Livni, E" uniqKey="Livni E">E Livni</name></author><author><name sortKey="Isacson, O" uniqKey="Isacson O">O Isacson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crotty, S" uniqKey="Crotty S">S Crotty</name></author><author><name sortKey="Fitzgerald, P" uniqKey="Fitzgerald P">P Fitzgerald</name></author><author><name sortKey="Tuohy, E" uniqKey="Tuohy E">E Tuohy</name></author><author><name sortKey="Harris, Dm" uniqKey="Harris D">DM Harris</name></author><author><name sortKey="Fisher, A" uniqKey="Fisher A">A Fisher</name></author><author><name sortKey="Mandel, A" uniqKey="Mandel A">A Mandel</name></author><author><name sortKey="Bolton, Ae" uniqKey="Bolton A">AE Bolton</name></author><author><name sortKey="Sullivan, Am" uniqKey="Sullivan A">AM Sullivan</name></author><author><name sortKey="Nolan, Y" uniqKey="Nolan Y">Y Nolan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Depino, Am" uniqKey="Depino A">AM Depino</name></author><author><name sortKey="Earl, C" uniqKey="Earl C">C Earl</name></author><author><name sortKey="Kaczmarczyk, E" uniqKey="Kaczmarczyk E">E Kaczmarczyk</name></author><author><name sortKey="Ferrari, C" uniqKey="Ferrari C">C Ferrari</name></author><author><name sortKey="Besedovsky, H" uniqKey="Besedovsky H">H Besedovsky</name></author><author><name sortKey="Del Rey, A" uniqKey="Del Rey A">A del Rey</name></author><author><name sortKey="Pitossi, Fj" uniqKey="Pitossi F">FJ Pitossi</name></author><author><name sortKey="Oertel, Wh" uniqKey="Oertel W">WH Oertel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koprich, Jb" uniqKey="Koprich J">JB Koprich</name></author><author><name sortKey="Reske Nielsen, C" uniqKey="Reske Nielsen C">C Reske-Nielsen</name></author><author><name sortKey="Mithal, P" uniqKey="Mithal P">P Mithal</name></author><author><name sortKey="Isacson, O" uniqKey="Isacson O">O Isacson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccoy, Mk" uniqKey="Mccoy M">MK McCoy</name></author><author><name sortKey="Martinez, Tn" uniqKey="Martinez T">TN Martinez</name></author><author><name sortKey="Ruhn, Ka" uniqKey="Ruhn K">KA Ruhn</name></author><author><name sortKey="Szymkowski, De" uniqKey="Szymkowski D">DE Szymkowski</name></author><author><name sortKey="Smith, Cg" uniqKey="Smith C">CG Smith</name></author><author><name sortKey="Botterman, Br" uniqKey="Botterman B">BR Botterman</name></author><author><name sortKey="Tansey, Ke" uniqKey="Tansey K">KE Tansey</name></author><author><name sortKey="Tansey, Mg" uniqKey="Tansey M">MG Tansey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Appel, S" uniqKey="Appel S">S Appel</name></author><author><name sortKey="Le, W" uniqKey="Le W">W Le</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castano, A" uniqKey="Castano A">A Castano</name></author><author><name sortKey="Herrera, Aj" uniqKey="Herrera A">AJ Herrera</name></author><author><name sortKey="Cano, J" uniqKey="Cano J">J Cano</name></author><author><name sortKey="Machado, A" uniqKey="Machado A">A Machado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Hm" uniqKey="Gao H">HM Gao</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name></author><author><name sortKey="Wilson, B" uniqKey="Wilson B">B Wilson</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Hong, Js" uniqKey="Hong J">JS Hong</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohutnicka, M" uniqKey="Kohutnicka M">M Kohutnicka</name></author><author><name sortKey="Lewandowska, E" uniqKey="Lewandowska E">E Lewandowska</name></author><author><name sortKey="Kurkowska Jastrzebska, I" uniqKey="Kurkowska Jastrzebska I">I Kurkowska-Jastrzebska</name></author><author><name sortKey="Czlonkowski, A" uniqKey="Czlonkowski A">A Czlonkowski</name></author><author><name sortKey="Czlonkowska, A" uniqKey="Czlonkowska A">A Czlonkowska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurkowska Jastrzebska, I" uniqKey="Kurkowska Jastrzebska I">I Kurkowska-Jastrzebska</name></author><author><name sortKey="Wronska, A" uniqKey="Wronska A">A Wronska</name></author><author><name sortKey="Kohutnicka, M" uniqKey="Kohutnicka M">M Kohutnicka</name></author><author><name sortKey="Czlonkowski, A" uniqKey="Czlonkowski A">A Czlonkowski</name></author><author><name sortKey="Czlonkowska, A" uniqKey="Czlonkowska A">A Czlonkowska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sriram, K" uniqKey="Sriram K">K Sriram</name></author><author><name sortKey="Matheson, Jm" uniqKey="Matheson J">JM Matheson</name></author><author><name sortKey="Benkovic, Sa" uniqKey="Benkovic S">SA Benkovic</name></author><author><name sortKey="Miller, Db" uniqKey="Miller D">DB Miller</name></author><author><name sortKey="Luster, Mi" uniqKey="Luster M">MI Luster</name></author><author><name sortKey="O Callaghan, Jp" uniqKey="O Callaghan J">JP O'Callaghan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sriram, K" uniqKey="Sriram K">K Sriram</name></author><author><name sortKey="Matheson, Jm" uniqKey="Matheson J">JM Matheson</name></author><author><name sortKey="Benkovic, Sa" uniqKey="Benkovic S">SA Benkovic</name></author><author><name sortKey="Miller, Db" uniqKey="Miller D">DB Miller</name></author><author><name sortKey="Luster, Mi" uniqKey="Luster M">MI Luster</name></author><author><name sortKey="O Callaghan, Jp" uniqKey="O Callaghan J">JP O'Callaghan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liberatore, Gt" uniqKey="Liberatore G">GT Liberatore</name></author><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Vukosavic, S" uniqKey="Vukosavic S">S Vukosavic</name></author><author><name sortKey="Mandir, As" uniqKey="Mandir A">AS Mandir</name></author><author><name sortKey="Vila, M" uniqKey="Vila M">M Vila</name></author><author><name sortKey="Mcauliffe, Wg" uniqKey="Mcauliffe W">WG McAuliffe</name></author><author><name sortKey="Dawson, Vl" uniqKey="Dawson V">VL Dawson</name></author><author><name sortKey="Dawson, Tm" uniqKey="Dawson T">TM Dawson</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teismann, P" uniqKey="Teismann P">P Teismann</name></author><author><name sortKey="Tieu, K" uniqKey="Tieu K">K Tieu</name></author><author><name sortKey="Choi, Dk" uniqKey="Choi D">DK Choi</name></author><author><name sortKey="Wu, Dc" uniqKey="Wu D">DC Wu</name></author><author><name sortKey="Naini, A" uniqKey="Naini A">A Naini</name></author><author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name></author><author><name sortKey="Vila, M" uniqKey="Vila M">M Vila</name></author><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teismann, P" uniqKey="Teismann P">P Teismann</name></author><author><name sortKey="Vila, M" uniqKey="Vila M">M Vila</name></author><author><name sortKey="Choi, Dk" uniqKey="Choi D">DK Choi</name></author><author><name sortKey="Tieu, K" uniqKey="Tieu K">K Tieu</name></author><author><name sortKey="Wu, Dc" uniqKey="Wu D">DC Wu</name></author><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Dc" uniqKey="Wu D">DC Wu</name></author><author><name sortKey="Teismann, P" uniqKey="Teismann P">P Teismann</name></author><author><name sortKey="Tieu, K" uniqKey="Tieu K">K Tieu</name></author><author><name sortKey="Vila, M" uniqKey="Vila M">M Vila</name></author><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Ischiropoulos, H" uniqKey="Ischiropoulos H">H Ischiropoulos</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name></author><author><name sortKey="Qin, L" uniqKey="Qin L">L Qin</name></author><author><name sortKey="Gao, Hm" uniqKey="Gao H">HM Gao</name></author><author><name sortKey="Wilson, B" uniqKey="Wilson B">B Wilson</name></author><author><name sortKey="Ali, Sf" uniqKey="Ali S">SF Ali</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Hong, Js" uniqKey="Hong J">JS Hong</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babior, Bm" uniqKey="Babior B">BM Babior</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulz, R" uniqKey="Schulz R">R Schulz</name></author><author><name sortKey="Panas, Dl" uniqKey="Panas D">DL Panas</name></author><author><name sortKey="Catena, R" uniqKey="Catena R">R Catena</name></author><author><name sortKey="Moncada, S" uniqKey="Moncada S">S Moncada</name></author><author><name sortKey="Olley, Pm" uniqKey="Olley P">PM Olley</name></author><author><name sortKey="Lopaschuk, Gd" uniqKey="Lopaschuk G">GD Lopaschuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, Zh" uniqKey="Feng Z">ZH Feng</name></author><author><name sortKey="Wang, Tg" uniqKey="Wang T">TG Wang</name></author><author><name sortKey="Li, Dd" uniqKey="Li D">DD Li</name></author><author><name sortKey="Fung, P" uniqKey="Fung P">P Fung</name></author><author><name sortKey="Wilson, Bc" uniqKey="Wilson B">BC Wilson</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author><author><name sortKey="Ali, Sf" uniqKey="Ali S">SF Ali</name></author><author><name sortKey="Langenbach, R" uniqKey="Langenbach R">R Langenbach</name></author><author><name sortKey="Hong, Js" uniqKey="Hong J">JS Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijitruth, R" uniqKey="Vijitruth R">R Vijitruth</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Choi, Dy" uniqKey="Choi D">DY Choi</name></author><author><name sortKey="Nguyen, Xv" uniqKey="Nguyen X">XV Nguyen</name></author><author><name sortKey="Hunter, Rl" uniqKey="Hunter R">RL Hunter</name></author><author><name sortKey="Bing, G" uniqKey="Bing G">G Bing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Needleman, P" uniqKey="Needleman P">P Needleman</name></author><author><name sortKey="Isakson, Pc" uniqKey="Isakson P">PC Isakson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author><author><name sortKey="Uematsu, S" uniqKey="Uematsu S">S Uematsu</name></author><author><name sortKey="Takeuchi, O" uniqKey="Takeuchi O">O Takeuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffmann, O" uniqKey="Hoffmann O">O Hoffmann</name></author><author><name sortKey="Braun, Js" uniqKey="Braun J">JS Braun</name></author><author><name sortKey="Becker, D" uniqKey="Becker D">D Becker</name></author><author><name sortKey="Halle, A" uniqKey="Halle A">A Halle</name></author><author><name sortKey="Freyer, D" uniqKey="Freyer D">D Freyer</name></author><author><name sortKey="Dagand, E" uniqKey="Dagand E">E Dagand</name></author><author><name sortKey="Lehnardt, S" uniqKey="Lehnardt S">S Lehnardt</name></author><author><name sortKey="Weber, Jr" uniqKey="Weber J">JR Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawai, T" uniqKey="Kawai T">T Kawai</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehnardt, S" uniqKey="Lehnardt S">S Lehnardt</name></author><author><name sortKey="Lehmann, S" uniqKey="Lehmann S">S Lehmann</name></author><author><name sortKey="Kaul, D" uniqKey="Kaul D">D Kaul</name></author><author><name sortKey="Tschimmel, K" uniqKey="Tschimmel K">K Tschimmel</name></author><author><name sortKey="Hoffmann, O" uniqKey="Hoffmann O">O Hoffmann</name></author><author><name sortKey="Cho, S" uniqKey="Cho S">S Cho</name></author><author><name sortKey="Krueger, C" uniqKey="Krueger C">C Krueger</name></author><author><name sortKey="Nitsch, R" uniqKey="Nitsch R">R Nitsch</name></author><author><name sortKey="Meisel, A" uniqKey="Meisel A">A Meisel</name></author><author><name sortKey="Weber, Jr" uniqKey="Weber J">JR Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apetoh, L" uniqKey="Apetoh L">L Apetoh</name></author><author><name sortKey="Ghiringhelli, F" uniqKey="Ghiringhelli F">F Ghiringhelli</name></author><author><name sortKey="Tesniere, A" uniqKey="Tesniere A">A Tesniere</name></author><author><name sortKey="Obeid, M" uniqKey="Obeid M">M Obeid</name></author><author><name sortKey="Ortiz, C" uniqKey="Ortiz C">C Ortiz</name></author><author><name sortKey="Criollo, A" uniqKey="Criollo A">A Criollo</name></author><author><name sortKey="Mignot, G" uniqKey="Mignot G">G Mignot</name></author><author><name sortKey="Maiuri, Mc" uniqKey="Maiuri M">MC Maiuri</name></author><author><name sortKey="Ullrich, E" uniqKey="Ullrich E">E Ullrich</name></author><author><name sortKey="Saulnier, P" uniqKey="Saulnier P">P Saulnier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vogl, T" uniqKey="Vogl T">T Vogl</name></author><author><name sortKey="Tenbrock, K" uniqKey="Tenbrock K">K Tenbrock</name></author><author><name sortKey="Ludwig, S" uniqKey="Ludwig S">S Ludwig</name></author><author><name sortKey="Leukert, N" uniqKey="Leukert N">N Leukert</name></author><author><name sortKey="Ehrhardt, C" uniqKey="Ehrhardt C">C Ehrhardt</name></author><author><name sortKey="Van Zoelen, Ma" uniqKey="Van Zoelen M">MA van Zoelen</name></author><author><name sortKey="Nacken, W" uniqKey="Nacken W">W Nacken</name></author><author><name sortKey="Foell, D" uniqKey="Foell D">D Foell</name></author><author><name sortKey="Van Der Poll, T" uniqKey="Van Der Poll T">T van der Poll</name></author><author><name sortKey="Sorg, C" uniqKey="Sorg C">C Sorg</name></author><author><name sortKey="Roth, J" uniqKey="Roth J">J Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janssens, S" uniqKey="Janssens S">S Janssens</name></author><author><name sortKey="Beyaert, R" uniqKey="Beyaert R">R Beyaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunne, A" uniqKey="Dunne A">A Dunne</name></author><author><name sortKey="O Neill, La" uniqKey="O Neill L">LA O'Neill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, J" uniqKey="Kang J">J Kang</name></author><author><name sortKey="Rivest, S" uniqKey="Rivest S">S Rivest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hao, W" uniqKey="Hao W">W Hao</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Walter, S" uniqKey="Walter S">S Walter</name></author><author><name sortKey="Grimm, Mo" uniqKey="Grimm M">MO Grimm</name></author><author><name sortKey="Kiliaan, Aj" uniqKey="Kiliaan A">AJ Kiliaan</name></author><author><name sortKey="Penke, B" uniqKey="Penke B">B Penke</name></author><author><name sortKey="Hartmann, T" uniqKey="Hartmann T">T Hartmann</name></author><author><name sortKey="Rube, Ce" uniqKey="Rube C">CE Rube</name></author><author><name sortKey="Menger, Md" uniqKey="Menger M">MD Menger</name></author><author><name sortKey="Fassbender, K" uniqKey="Fassbender K">K Fassbender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Panaro, Ma" uniqKey="Panaro M">MA Panaro</name></author><author><name sortKey="Lofrumento, Dd" uniqKey="Lofrumento D">DD Lofrumento</name></author><author><name sortKey="Saponaro, C" uniqKey="Saponaro C">C Saponaro</name></author><author><name sortKey="De Nuccio, F" uniqKey="De Nuccio F">F De Nuccio</name></author><author><name sortKey="Cianciulli, A" uniqKey="Cianciulli A">A Cianciulli</name></author><author><name sortKey="Mitolo, V" uniqKey="Mitolo V">V Mitolo</name></author><author><name sortKey="Nicolardi, G" uniqKey="Nicolardi G">G Nicolardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ros Bernal, F" uniqKey="Ros Bernal F">F Ros-Bernal</name></author><author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name></author><author><name sortKey="Herrero, Mt" uniqKey="Herrero M">MT Herrero</name></author><author><name sortKey="Parnadeau, S" uniqKey="Parnadeau S">S Parnadeau</name></author><author><name sortKey="Corvol, Jc" uniqKey="Corvol J">JC Corvol</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Alvarez Fischer, D" uniqKey="Alvarez Fischer D">D Alvarez-Fischer</name></author><author><name sortKey="Carrillo De Sauvage, Ma" uniqKey="Carrillo De Sauvage M">MA Carrillo-de Sauvage</name></author><author><name sortKey="Saurini, F" uniqKey="Saurini F">F Saurini</name></author><author><name sortKey="Coussieu, C" uniqKey="Coussieu C">C Coussieu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stefanova, N" uniqKey="Stefanova N">N Stefanova</name></author><author><name sortKey="Fellner, L" uniqKey="Fellner L">L Fellner</name></author><author><name sortKey="Reindl, M" uniqKey="Reindl M">M Reindl</name></author><author><name sortKey="Masliah, E" uniqKey="Masliah E">E Masliah</name></author><author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name></author><author><name sortKey="Wenning, Gk" uniqKey="Wenning G">GK Wenning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cote, M" uniqKey="Cote M">M Cote</name></author><author><name sortKey="Drouin Ouellet, J" uniqKey="Drouin Ouellet J">J Drouin-Ouellet</name></author><author><name sortKey="Cicchetti, F" uniqKey="Cicchetti F">F Cicchetti</name></author><author><name sortKey="Soulet, D" uniqKey="Soulet D">D Soulet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Djaldetti, R" uniqKey="Djaldetti R">R Djaldetti</name></author><author><name sortKey="Liberatore, G" uniqKey="Liberatore G">G Liberatore</name></author><author><name sortKey="Vila, M" uniqKey="Vila M">M Vila</name></author><author><name sortKey="Vukosavic, S" uniqKey="Vukosavic S">S Vukosavic</name></author><author><name sortKey="Almer, G" uniqKey="Almer G">G Almer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Naini, Ab" uniqKey="Naini A">AB Naini</name></author><author><name sortKey="Jakowec, M" uniqKey="Jakowec M">M Jakowec</name></author><author><name sortKey="Petzinger, G" uniqKey="Petzinger G">G Petzinger</name></author><author><name sortKey="Miller, R" uniqKey="Miller R">R Miller</name></author><author><name sortKey="Akram, M" uniqKey="Akram M">M Akram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adachi, O" uniqKey="Adachi O">O Adachi</name></author><author><name sortKey="Kawai, T" uniqKey="Kawai T">T Kawai</name></author><author><name sortKey="Takeda, K" uniqKey="Takeda K">K Takeda</name></author><author><name sortKey="Matsumoto, M" uniqKey="Matsumoto M">M Matsumoto</name></author><author><name sortKey="Tsutsui, H" uniqKey="Tsutsui H">H Tsutsui</name></author><author><name sortKey="Sakagami, M" uniqKey="Sakagami M">M Sakagami</name></author><author><name sortKey="Nakanishi, K" uniqKey="Nakanishi K">K Nakanishi</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawai, T" uniqKey="Kawai T">T Kawai</name></author><author><name sortKey="Adachi, O" uniqKey="Adachi O">O Adachi</name></author><author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name></author><author><name sortKey="Takeda, K" uniqKey="Takeda K">K Takeda</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibrat, C" uniqKey="Gibrat C">C Gibrat</name></author><author><name sortKey="Saint Pierre, M" uniqKey="Saint Pierre M">M Saint-Pierre</name></author><author><name sortKey="Bousquet, M" uniqKey="Bousquet M">M Bousquet</name></author><author><name sortKey="Levesque, D" uniqKey="Levesque D">D Levesque</name></author><author><name sortKey="Rouillard, C" uniqKey="Rouillard C">C Rouillard</name></author><author><name sortKey="Cicchetti, F" uniqKey="Cicchetti F">F Cicchetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lalancette Hebert, M" uniqKey="Lalancette Hebert M">M Lalancette-Hebert</name></author><author><name sortKey="Phaneuf, D" uniqKey="Phaneuf D">D Phaneuf</name></author><author><name sortKey="Soucy, G" uniqKey="Soucy G">G Soucy</name></author><author><name sortKey="Weng, Yc" uniqKey="Weng Y">YC Weng</name></author><author><name sortKey="Kriz, J" uniqKey="Kriz J">J Kriz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bousquet, M" uniqKey="Bousquet M">M Bousquet</name></author><author><name sortKey="Gue, K" uniqKey="Gue K">K Gue</name></author><author><name sortKey="Emond, V" uniqKey="Emond V">V Emond</name></author><author><name sortKey="Julien, P" uniqKey="Julien P">P Julien</name></author><author><name sortKey="Kang, Jx" uniqKey="Kang J">JX Kang</name></author><author><name sortKey="Cicchetti, F" uniqKey="Cicchetti F">F Cicchetti</name></author><author><name sortKey="Calon, F" uniqKey="Calon F">F Calon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franklin, Kbj" uniqKey="Franklin K">KBJ Franklin</name></author><author><name sortKey="Paxinos, G" uniqKey="Paxinos G">G Paxinos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glaser, Jr" uniqKey="Glaser J">JR Glaser</name></author><author><name sortKey="Glaser, Em" uniqKey="Glaser E">EM Glaser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calon, F" uniqKey="Calon F">F Calon</name></author><author><name sortKey="Lavertu, N" uniqKey="Lavertu N">N Lavertu</name></author><author><name sortKey="Lemieux, Am" uniqKey="Lemieux A">AM Lemieux</name></author><author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name></author><author><name sortKey="Goulet, M" uniqKey="Goulet M">M Goulet</name></author><author><name sortKey="Grondin, R" uniqKey="Grondin R">R Grondin</name></author><author><name sortKey="Blanchet, Pj" uniqKey="Blanchet P">PJ Blanchet</name></author><author><name sortKey="Bedard, Pj" uniqKey="Bedard P">PJ Bedard</name></author><author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breidert, T" uniqKey="Breidert T">T Breidert</name></author><author><name sortKey="Callebert, J" uniqKey="Callebert J">J Callebert</name></author><author><name sortKey="Heneka, Mt" uniqKey="Heneka M">MT Heneka</name></author><author><name sortKey="Landreth, G" uniqKey="Landreth G">G Landreth</name></author><author><name sortKey="Launay, Jm" uniqKey="Launay J">JM Launay</name></author><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Dk" uniqKey="Choi D">DK Choi</name></author><author><name sortKey="Pennathur, S" uniqKey="Pennathur S">S Pennathur</name></author><author><name sortKey="Perier, C" uniqKey="Perier C">C Perier</name></author><author><name sortKey="Tieu, K" uniqKey="Tieu K">K Tieu</name></author><author><name sortKey="Teismann, P" uniqKey="Teismann P">P Teismann</name></author><author><name sortKey="Wu, Dc" uniqKey="Wu D">DC Wu</name></author><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Vila, M" uniqKey="Vila M">M Vila</name></author><author><name sortKey="Vonsattel, Jp" uniqKey="Vonsattel J">JP Vonsattel</name></author><author><name sortKey="Heinecke, Jw" uniqKey="Heinecke J">JW Heinecke</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Pf" uniqKey="Smith P">PF Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brochard, V" uniqKey="Brochard V">V Brochard</name></author><author><name sortKey="Combadiere, B" uniqKey="Combadiere B">B Combadiere</name></author><author><name sortKey="Prigent, A" uniqKey="Prigent A">A Prigent</name></author><author><name sortKey="Laouar, Y" uniqKey="Laouar Y">Y Laouar</name></author><author><name sortKey="Perrin, A" uniqKey="Perrin A">A Perrin</name></author><author><name sortKey="Beray Berthat, V" uniqKey="Beray Berthat V">V Beray-Berthat</name></author><author><name sortKey="Bonduelle, O" uniqKey="Bonduelle O">O Bonduelle</name></author><author><name sortKey="Alvarez Fischer, D" uniqKey="Alvarez Fischer D">D Alvarez-Fischer</name></author><author><name sortKey="Callebert, J" uniqKey="Callebert J">J Callebert</name></author><author><name sortKey="Launay, Jm" uniqKey="Launay J">JM Launay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author><author><name sortKey="Wang, K" uniqKey="Wang K">K Wang</name></author><author><name sortKey="Gao, Hm" uniqKey="Gao H">HM Gao</name></author><author><name sortKey="Mandavilli, B" uniqKey="Mandavilli B">B Mandavilli</name></author><author><name sortKey="Wang, Jy" uniqKey="Wang J">JY Wang</name></author><author><name sortKey="Hong, Js" uniqKey="Hong J">JS Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peterson, Jw" uniqKey="Peterson J">JW Peterson</name></author><author><name sortKey="Bo, L" uniqKey="Bo L">L Bo</name></author><author><name sortKey="Mork, S" uniqKey="Mork S">S Mork</name></author><author><name sortKey="Chang, A" uniqKey="Chang A">A Chang</name></author><author><name sortKey="Ransohoff, Rm" uniqKey="Ransohoff R">RM Ransohoff</name></author><author><name sortKey="Trapp, Bd" uniqKey="Trapp B">BD Trapp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olson, Jk" uniqKey="Olson J">JK Olson</name></author><author><name sortKey="Miller, Sd" uniqKey="Miller S">SD Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuya, T" uniqKey="Furuya T">T Furuya</name></author><author><name sortKey="Hayakawa, H" uniqKey="Hayakawa H">H Hayakawa</name></author><author><name sortKey="Yamada, M" uniqKey="Yamada M">M Yamada</name></author><author><name sortKey="Yoshimi, K" uniqKey="Yoshimi K">K Yoshimi</name></author><author><name sortKey="Hisahara, S" uniqKey="Hisahara S">S Hisahara</name></author><author><name sortKey="Miura, M" uniqKey="Miura M">M Miura</name></author><author><name sortKey="Mizuno, Y" uniqKey="Mizuno Y">Y Mizuno</name></author><author><name sortKey="Mochizuki, H" uniqKey="Mochizuki H">H Mochizuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mochizuki, H" uniqKey="Mochizuki H">H Mochizuki</name></author><author><name sortKey="Hayakawa, H" uniqKey="Hayakawa H">H Hayakawa</name></author><author><name sortKey="Migita, M" uniqKey="Migita M">M Migita</name></author><author><name sortKey="Shibata, M" uniqKey="Shibata M">M Shibata</name></author><author><name sortKey="Tanaka, R" uniqKey="Tanaka R">R Tanaka</name></author><author><name sortKey="Suzuki, A" uniqKey="Suzuki A">A Suzuki</name></author><author><name sortKey="Shimo Nakanishi, Y" uniqKey="Shimo Nakanishi Y">Y Shimo-Nakanishi</name></author><author><name sortKey="Urabe, T" uniqKey="Urabe T">T Urabe</name></author><author><name sortKey="Yamada, M" uniqKey="Yamada M">M Yamada</name></author><author><name sortKey="Tamayose, K" uniqKey="Tamayose K">K Tamayose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tatton, Na" uniqKey="Tatton N">NA Tatton</name></author><author><name sortKey="Kish, Sj" uniqKey="Kish S">SJ Kish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ng" uniqKey="Kim N">NG Kim</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H Lee</name></author><author><name sortKey="Son, E" uniqKey="Son E">E Son</name></author><author><name sortKey="Kwon, Oy" uniqKey="Kwon O">OY Kwon</name></author><author><name sortKey="Park, Jy" uniqKey="Park J">JY Park</name></author><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author><author><name sortKey="Cho, Gj" uniqKey="Cho G">GJ Cho</name></author><author><name sortKey="Choi, Ws" uniqKey="Choi W">WS Choi</name></author><author><name sortKey="Suk, K" uniqKey="Suk K">K Suk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Ja" uniqKey="Miller J">JA Miller</name></author><author><name sortKey="Trout, Br" uniqKey="Trout B">BR Trout</name></author><author><name sortKey="Sullivan, Ka" uniqKey="Sullivan K">KA Sullivan</name></author><author><name sortKey="Bialecki, Ra" uniqKey="Bialecki R">RA Bialecki</name></author><author><name sortKey="Roberts, Ra" uniqKey="Roberts R">RA Roberts</name></author><author><name sortKey="Tjalkens, Rb" uniqKey="Tjalkens R">RB Tjalkens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author><author><name sortKey="Takeda, K" uniqKey="Takeda K">K Takeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caso, Jr" uniqKey="Caso J">JR Caso</name></author><author><name sortKey="Pradillo, Jm" uniqKey="Pradillo J">JM Pradillo</name></author><author><name sortKey="Hurtado, O" uniqKey="Hurtado O">O Hurtado</name></author><author><name sortKey="Leza, Jc" uniqKey="Leza J">JC Leza</name></author><author><name sortKey="Moro, Ma" uniqKey="Moro M">MA Moro</name></author><author><name sortKey="Lizasoain, I" uniqKey="Lizasoain I">I Lizasoain</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Drouin Ouellet, Janelle" sort="Drouin Ouellet, Janelle" uniqKey="Drouin Ouellet J" first="Janelle" last="Drouin-Ouellet">Janelle Drouin-Ouellet</name></noRegion><name sortKey="Bousquet, Melanie" sort="Bousquet, Melanie" uniqKey="Bousquet M" first="Mélanie" last="Bousquet">Mélanie Bousquet</name><name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frédéric" last="Calon">Frédéric Calon</name><name sortKey="Cicchetti, Francesca" sort="Cicchetti, Francesca" uniqKey="Cicchetti F" first="Francesca" last="Cicchetti">Francesca Cicchetti</name><name sortKey="Gibrat, Claire" sort="Gibrat, Claire" uniqKey="Gibrat C" first="Claire" last="Gibrat">Claire Gibrat</name><name sortKey="Kriz, Jasna" sort="Kriz, Jasna" uniqKey="Kriz J" first="Jasna" last="Kriz">Jasna Kriz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001575 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001575 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3203853
|texte= The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21989292" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |